Sepsis is an abnormal immune response to severe infection, which can rapidly lead to tissue damage, organ failure, and death.

Due to excessive inflammation, sepsis can lead to septic shock, an abnormality in the circulatory and metabolic system, with a 40% mortality rate worldwide.

As sepsis does not have a specific treatment, patients in the ICU are given antibiotics, vasopressors, fluids, and supportive care

Sepsis patient’s pathology is very heterogenous: acute death due to hyperinflammation or re-infection due to immune paralysis. Need for precision medicine that could simultaneously diagnose and treat the heterogeneous conditions of sepsis patients (Hyperinflammation vs. Immune paralysis)